SV40 Virus and Mesothelioma

SV40 Virus and Mesothelioma


Malignant mesothelioma has been linked to asbestos exposure. End of the century thousands of cases of disease are found in individuals who routinely work with toxic minerals in a variety of different jobs. However, after a report that was released about 30 years ago by McDonald and McDonald determined that approximately 25-33 percent of all diagnosed cases of mesothelioma cancer has no definite connection with asbestos exposure. A person who has been diagnosed with mesothelioma cancer is never any contact with asbestos or asbestos-containing materials.

For years researchers have found several other potential causes for the cause of the growth of mesothelioma. One of the patients with mesothelioma may be exposed to Simian Virus 40 (SV40).

Whether SV40?

SV40 is a virus which was first discovered in 1960. The virus is found in the kidney cells of rhesus monkeys. It causes kidney disease and certain cancers in a population of monkeys. This virus also attacks certain tumor suppressor genes and cell death.

Simian Virus 40 U.S. public concern when it is certain that the kidney cells of rhesus monkeys was used in the manufacture of polio vaccine given to humans. This vaccine has been used from 1958 to 1963 and was given to nearly 100 million Americans. There is a sizeable amount of contaminated vaccine Simian Virus 40 and given to humans during that time period. Although exact figures are not recorded how many doses of virus contamination are given, but estimated between 10 to 30 million doses.

SV40 and Mesothelioma

Since the discovery of Simian virus 40 in millions of doses of polio vaccine, researchers have been looking for a relationship between virus and cancer development in humans. Several studies have found that SV40 is present in many people diagnosed with the disease mesothelioma.

A study led by Dr. Michele Carbone is one of the leading mesothelioma specialists in the U.S., determined that more than half (approximately 54%) of all cases of malignant mesothelioma cancer have been infected with SV40 (Carbone, M. "Simian virus 40 and human tumors: It is time to study Mechanisms. "). But they did not find the SV40 contamination in other types of lung cancer. This strengthens the finding that there is a link between SV40 and asbestos cancer, but there is no full proof that the only course that SV40 causes mesothelioma. Doctors gave the hypothesis that exposure to asbestos or immunosuppression may also be involved in this case.

A similar study conducted in 2008 in Hawaii Cancer Research Center and Department of Pathology, University of Hawaii, concluded that about 60 percent of the hamsters injected with Simian Virus 40 intrakardial died of mesothelioma. But the significant role of SV40 in human malignant mesothelioma remains debatable (Rivera et al, "The Relationship Between Simian Virus 40 and Mesothelioma"). The short conclusion the authors report: "There is sufficient evidence regarding the relationship between simian virus 40 on its own or together as a trigger of malignant mesothelioma asbestos. But it is still not enough to speculate about the contribution of simian virus 40 with the overall incidence of pleural mesothelioma (pleural mesothelioma chest). "

SV40 and asbestos

Additional studies noted that the combination of the presence of SV40 and asbestos exposure greatly increases the chances often occur in the development of mesothelioma. In a 2005 report by a number of doctors and scientists Italy (Cristaudo et al, "SV40 Enhances the Risk of Malignant Mesothelioma Among People Exposed to Asbestos: A Molecular Epidemiologic Case-Control Study"), the authors hypothesize that SV40 contributes to cancer development only as an additional factor and not a direct cause.

More importantly, this study determined that "SV40 detection between groups of individuals exposed to asbestos could represent a useful marker to identify those at high risk for MM (Malignant Mesothelioma - malignant mesothelioma). Subgroup of high risk individuals can be monitored for early detection and curative surgical excision may be performed ".

Some doctors continue to seek better ways to diagnose mesothelioma in early stages, karenan identify high-risk individuals such as this equates to saving many lives.


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